Obesity for Translational Gastroenterology- myassignmenthelp.com

Question: Discuss about theObesity for Clinical and Translational Gastroenterology. Answer: Introduction The paper deals with the effect of obesity on intestinal barrier function. Further, the relation of obesity to IBD is explained. Effect of obesity on intestinal barrier function Obesity is associated with metabolic alterations in the body such as insulin resistance and glucose intolerance. Metabolic syndrome manifest as low-grade systemic inflammation and is directly associated with the intestinal barriers dysfunction. Inflammation is caused by the lipopolysaccharide or LPS derived from the gut microbiota. This factor is associated with the metabolic disease linked to obesity. LPS is the major component of bacterial cell wall (gram negative bacteria). These bacteria can induce inflammation. Intestinal epithelium acts as barrier in normal physiological conditions and inhibits the LPS translocation (Walters et al. 2014). People with obesity consume high fat diet. The barrier function is changed by the high fat diet due to reducing thickness of mucous layer. Thus, it is easy for the microbes to destroy the tight junction protein and destroy the intestinal permeability. Poor permeability allows greater access of bacteria to intestinal route. It consequently incr eases the inflammatory process resulting in intestinal tissue injury wall. It results in inflammatory bowel disease or IBD (Seminerio et al. 2015). Thus, obesity is associated with IBD. Several experiments conducted with mice model showed manifestation of inflammatory bowel disease showed clear defect in epithelial barrier defects. In mice models, epithelial tight junction proteins were poorly expressed when kept on high fat diet (Knig et al. 2016). Conclusion In conclusion obesity negatively impacts the intestinal barrier function leading to increases in inflammatory process initiated by bacteria. This barrier injury is manifest as IBD. Hence, obesity is related to IBD via metabolic alterations. References Knig, J., Wells, J., Cani, P.D., Garca-Rdenas, C.L., MacDonald, T., Mercenier, A., Whyte, J., Troost, F. and Brummer, R.J., 2016. Human intestinal barrier function in health and disease.Clinical and translational gastroenterology,7(10), p.e196. Seminerio, J.L., Koutroubakis, I.E., Ramos-Rivers, C., Hashash, J.G., Dudekula, A., Regueiro, M., Baidoo, L., Barrie, A., Swoger, J., Schwartz, M. and Weyant, K., 2015. Impact of obesity on the management and clinical course of patients with inflammatory bowel disease.Inflammatory bowel diseases,21(12), pp.2857-2863. Walters, W.A., Xu, Z. and Knight, R., 2014. Meta?analyses of human gut microbes associated with obesity and IBD.FEBS letters,588(22), pp.4223-4233.